Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain

Persistent pain induced by noxious stimuli is characterized by the transition from normosensitivity to hypersensitivity. Underlying mechanisms are not well understood, although gene expression is considered important. Here we show that persistent nociceptive-like activity triggers calcium transients...

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Main Authors: Simonetti, Manuela, Hagenston, Anna M., Vardeh, Daniel, Freitag, H. Eckehard, Mauceri, Daniela, Lu, Jianning, Satagopam, Venkata P., Schneider, Reinhard, Costigan, Michael, Bading, Hilmar, Kuner, Rohini
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593630/
https://ncbi.nlm.nih.gov/pubmed/23312515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.10.037
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