Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain

Persistent pain induced by noxious stimuli is characterized by the transition from normosensitivity to hypersensitivity. Underlying mechanisms are not well understood, although gene expression is considered important. Here we show that persistent nociceptive-like activity triggers calcium transients...

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Autori principali: Simonetti, Manuela, Hagenston, Anna M., Vardeh, Daniel, Freitag, H. Eckehard, Mauceri, Daniela, Lu, Jianning, Satagopam, Venkata P., Schneider, Reinhard, Costigan, Michael, Bading, Hilmar, Kuner, Rohini
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593630/
https://ncbi.nlm.nih.gov/pubmed/23312515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.10.037
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