Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

Binding of type I interferons (IFNs) to their receptors induces rapid tyrosine phosphorylation of multiple proteins, including the alpha and beta subunits of the receptor, the polypeptides that form the transcriptional activator ISGF3 alpha (Stat113, Stat84, and Stat91), and the p135tyk2 and Jak-1 t...

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Main Authors: Colamonici, O, Yan, H, Domanski, P, Handa, R, Smalley, D, Mullersman, J, Witte, M, Krishnan, K, Krolewski, J
Formato: Artigo
Idioma:Inglês
Publicado: 1994
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC359352/
https://ncbi.nlm.nih.gov/pubmed/7526154
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