Suppression of Adipogenesis by Pathogenic Seipin Mutant Is Associated with Inflammatory Response

BACKGROUND: While pathogenic mutations in BSCL2/Seipin cause congenital generalized lipodystrophy, the underlying mechanism is largely unknown. In this study, we investigated whether and how the pathogenic missense A212P mutation of Seipin (Seipin-A212P) inhibits adipogenesis. METHODOLOGY/RESULTS: W...

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Hlavní autoři: Qiu, Wenjie, Wee, Kenneth, Takeda, Kosuke, Lim, Xuemei, Sugii, Shigeki, Radda, George K., Han, Weiping
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592919/
https://ncbi.nlm.nih.gov/pubmed/23520483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057874
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