Multiple Sites of the Cleavage of 21- and 25-Mer Encephalytogenic Oligopeptides Corresponding to Human Myelin Basic Protein (MBP) by Specific Anti-MBP Antibodies from Patients with Systemic Lupus Erythematosus

IgGs from patients with multiple sclerosis and systemic lupus erythematosus (SLE) purified on MBP-Sepharose in contrast to canonical proteases hydrolyze effectively only myelin basic protein (MBP), but not many other tested proteins. Here we have shown for the first time that anti-MBP SLE IgGs hydro...

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Main Authors: Timofeeva, Anna M., Dmitrenok, Pavel S., Konenkova, Ludmila P., Buneva, Valentina N., Nevinsky, Georgy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592856/
https://ncbi.nlm.nih.gov/pubmed/23520443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051600
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