Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint

Human DNA polymerase (pol) λ functions in base excision repair and non-homologous end joining. We have previously shown that DNA pol λ is involved in accurate bypass of the two frequent oxidative lesions, 7,8-dihydro-8-oxoguanine and 1,2-dihydro-2-oxoadenine during the S phase. However, nothing is k...

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Detalhes bibliográficos
Main Authors: Zucca, Elisa, Bertoletti, Federica, Wimmer, Ursula, Ferrari, Elena, Mazzini, Giuliano, Khoronenkova, Svetlana, Grosse, Nicole, van Loon, Barbara, Dianov, Grigory, Hübscher, Ulrich, Maga, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592438/
https://ncbi.nlm.nih.gov/pubmed/23118481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1016
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