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The Absence of M1 Leads to Increased Establishment of Murine Gammaherpesvirus 68 Latency in IgD-Negative B Cells

The secreted M1 protein of murine gammaherpesvirus 68 (MHV68) promotes effector Vβ4(+) CD8(+) T cell expansion to impact virus control and immune-mediated pathologies in C57BL/6 mice, but not BALB/c mice. We report a striking increase in the number of genome-positive, IgD(−) B cells during chronic i...

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Detalhes bibliográficos
Main Authors: Krug, Laurie T., Evans, Andrew G., Gargano, Lisa M., Paden, Clinton R., Speck, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592133/
https://ncbi.nlm.nih.gov/pubmed/23302876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01953-12
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