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A Mutation in the Ebola Virus Envelope Glycoprotein Restricts Viral Entry in a Host Species- and Cell-Type-Specific Manner

Zaire Ebola virus (EBOV) is a zoonotic pathogen that causes severe hemorrhagic fever in humans. A single viral glycoprotein (GP) mediates viral attachment and entry. Here, virus-like particle (VLP)-based entry assays demonstrate that a GP mutant, GP-F88A, which is defective for entry into a variety...

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Detalhes bibliográficos
Main Authors: Martinez, Osvaldo, Ndungo, Esther, Tantral, Lee, Miller, Emily Happy, Leung, Lawrence W., Chandran, Kartik, Basler, Christopher F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592116/
https://ncbi.nlm.nih.gov/pubmed/23302883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01598-12
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