Suppressed cellular oscillations in after-hours mutant mice are associated with enhanced circadian phase-resetting

Within the core molecular clock, protein phosphorylation and degradation play a vital role in determining circadian period. The ‘after-hours’ (Afh) mutation in mouse slows the degradation of the core clock protein Cryptochrome, lengthening the period of the molecular clock in the suprachiasmatic nuc...

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Hlavní autoři: Guilding, Clare, Scott, Fiona, Bechtold, David A, Brown, Timothy M, Wegner, Sven, Piggins, Hugh D
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2013
Témata:
Neuroscience: Behavioural/Systems/Cognitive
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591715/
https://ncbi.nlm.nih.gov/pubmed/23207594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.242198
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