Ion channels in genetic and acquired forms of epilepsy

Genetic mutations causing dysfunction of both voltage- and ligand-gated ion channels make a major contribution to the cause of many different types of familial epilepsy. Key mechanisms comprise defective Na(+) channels of inhibitory neurons, or GABA(A) receptors affecting pre- or postsynaptic GABAer...

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Autores principales: Lerche, Holger, Shah, Mala, Beck, Heinz, Noebels, Jeff, Johnston, Dan, Vincent, Angela
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2013
Materias:
Symposium Section Reviews: Why Do Some Brains Seize? Molecular, Cellular and Network Mechanisms
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591694/
https://ncbi.nlm.nih.gov/pubmed/23090947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.240606
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