Transcriptome Analysis of Proximal Tubular Cells (HK-2) Exposed to Urines of Type 1 Diabetes Patients at Risk of Early Progressive Renal Function Decline

BACKGROUND: In patients with Type 1 Diabetes (T1D) who develop microalbuminuria, progressive decline in glomerular filtration rate (GFR) may be initiated by leakage into the urine of toxic proteins (txUPs). This study tested this hypothesis. METHODS: After archiving baseline urine, we followed T1D p...

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Autors principals: Wanic, Krzysztof, Krolewski, Bozena, Ju, Wenjun, Placha, Grzegorz, Niewczas, Monika A., Walker, William, Warram, James H., Kretzler, Matthias, Krolewski, Andrzej S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591403/
https://ncbi.nlm.nih.gov/pubmed/23505438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057751
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