A Frequent PNPLA3 Variant Is a Sex Specific Disease Modifier in PSC Patients with Bile Duct Stenosis

BACKGROUND & AIMS: Primary sclerosing cholangitis predominantly affects males and is an important indication for liver transplantation. The rs738409 variant (I148M) of the PNPLA3 gene is associated with alcoholic and non-alcoholic liver disease and we evaluated its impact on the disease course o...

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Main Authors: Friedrich, Kilian, Rupp, Christian, Hov, Johannes Roksund, Steinebrunner, Niels, Weiss, Karl-Heinz, Stiehl, Adolf, Brune, Maik, Schaefer, Petra Kloeters Yvonne, Schemmer, Peter, Sauer, Peter, Schirmacher, Peter, Runz, Heiko, Karlsen, Tom Hemming, Stremmel, Wolfgang, Gotthardt, Daniel Nils
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591368/
https://ncbi.nlm.nih.gov/pubmed/23505555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058734
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