Alantolactone Induces Apoptosis in HepG2 Cells through GSH Depletion, Inhibition of STAT3 Activation, and Mitochondrial Dysfunction

Signal transducer and activator of transcription 3 (STAT3) constitutively expresses in human liver cancer cells and has been implicated in apoptosis resistance and tumorigenesis. Alantolactone, a sesquiterpene lactone, has been shown to possess anticancer activities in various cancer cell lines. In...

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Detalhes bibliográficos
Main Authors: Khan, Muhammad, Li, Ting, Ahmad Khan, Muhammad Khalil, Rasul, Azhar, Nawaz, Faisal, Sun, Meiyan, Zheng, Yongchen, Ma, Tonghui
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591150/
https://ncbi.nlm.nih.gov/pubmed/23533997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/719858
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