Downregulation of DLC-1 Gene by Promoter Methylation during Primary Colorectal Cancer Progression

Purpose. DLC-1 is a tumor suppressor gene frequently silenced in human cancers. However, the pathogenicity of DLC-1 epigenetic silencing in the mucosa-adenoma-carcinoma transformation process of colorectal cancer (CRC) has not been studied. Methods. Promoter methylation status of DLC-1 was evaluated...

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Detalhes bibliográficos
Main Authors: Peng, Haixia, Long, Feng, Wu, Zhiyuan, Chu, Yimin, Li, Ji, Kuai, Rong, Zhang, Jing, Kang, Zhihua, Zhang, Xinju, Guan, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591122/
https://ncbi.nlm.nih.gov/pubmed/23509688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/181384
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