Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors.
Previous investigations have shown that culture of freshly isolated hepatocytes under conventional conditions, i.e., on dried rat tail collagen in the presence of growth factors, facilitates cell growth but also causes an extensive down-regulation of most liver-specific functions. This dedifferentia...
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| Published in: | Mol Cell Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
1994
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359112/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8065319/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.9.5858-5869.1994 |
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