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Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis
Cohesin’s Smc1, Smc3, and kleisin subunits create a tripartite ring within which sister DNAs are entrapped. Evidence suggests that DNA enters through a gate created by transient dissociation of the Smc1/3 interface. Release at the onset of anaphase is triggered by proteolytic cleavage of kleisin. Le...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
European Molecular Biology Organization
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3590983/ https://ncbi.nlm.nih.gov/pubmed/23340528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.346 |
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