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TRAF4 restricts IL-17-mediated pathology and signaling processes
The effector T-cell subset, Th17, plays a significant role in the pathogenesis of multiple sclerosis as well as other autoimmune diseases. The signature cytokine, IL-17, engages the IL-17R and recruits the E3-ligase Act1 upon stimulation. In this study we examined the role of TRAF4 in IL-17 signalin...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3590847/ https://ncbi.nlm.nih.gov/pubmed/22649194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200470 |
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