Bullous Pemphigoid IgG Induces BP180 Internalization via a Macropinocytic Pathway

Bullous pemphigoid (BP) is an autoimmune blistering skin disease induced by pathogenic autoantibodies against a type II transmembrane protein (BP180, collagen type XVII, or BPAG2). In animal models, BP180 autoantibody-antigen interaction appears insufficient to develop blisters, but involvement of c...

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Bibliographische Detailangaben
Hauptverfasser: Hiroyasu, Sho, Ozawa, Toshiyuki, Kobayashi, Hiromi, Ishii, Masamitsu, Aoyama, Yumi, Kitajima, Yasuo, Hashimoto, Takashi, Jones, Jonathan C.R., Tsuruta, Daisuke
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2013
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590760/
https://ncbi.nlm.nih.gov/pubmed/23337823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.11.029
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