Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms

BACKGROUND: The molecular basis for the development of appendiceal mucinous tumours, which can be a cause of pseudomyxoma peritonei, remains largely unknown. METHODS: Thirty-five appendiceal mucinous neoplasms were analysed for GNAS and KRAS mutations. A functional analysis of mutant GNAS was perfor...

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Detalhes bibliográficos
Main Authors: Nishikawa, G, Sekine, S, Ogawa, R, Matsubara, A, Mori, T, Taniguchi, H, Kushima, R, Hiraoka, N, Tsuta, K, Tsuda, H, Kanai, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590682/
https://ncbi.nlm.nih.gov/pubmed/23403822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.47
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