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Epigenetic Modification of Sod2 in the Development of Diabetic Retinopathy and in the Metabolic Memory: Role of Histone Methylation

PURPOSE. Mitochondrial superoxide levels are elevated in the retina in diabetes, and their scavenging enzyme, MnSOD, becomes subnormal. The objective of this study is to investigate the role of histone methylation of Sod2, the gene that encodes MnSOD, in the development of diabetic retinopathy and i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhong, Qing, Kowluru, Renu A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Association for Research in Vision and Ophthalmology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590072/
https://ncbi.nlm.nih.gov/pubmed/23221071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10854
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