Covariate adjustment increased power in randomized controlled trials: an example in traumatic brain injury

OBJECTIVE: We aimed to determine to what extent covariate adjustment could affect power in a randomized controlled trial (RCT) of a heterogeneous population with traumatic brain injury (TBI). STUDY DESIGN AND SETTING: We analyzed 14-day mortality in 9497 participants in the Corticosteroid Randomisat...

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Bibliographische Detailangaben
Hauptverfasser: Turner, Elizabeth L., Perel, Pablo, Clayton, Tim, Edwards, Phil, Hernández, Adrian V., Roberts, Ian, Shakur, Haleema, Steyerberg, Ewout W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589911/
https://ncbi.nlm.nih.gov/pubmed/22169080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jclinepi.2011.08.012
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