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P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

Microglia in the dorsal horn of the spinal cord are increasingly recognized as being crucial in the pathogenesis of pain hypersensitivity after injury to a peripheral nerve. It is known that P2X4 purinoceptors (P2X4Rs) cause the release of brain-derived neurotrophic factor (BDNF) from microglia, whi...

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Detalhes bibliográficos
Main Authors: Trang, Tuan, Beggs, Simon, Wan, Xiang, Salter, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589565/
https://ncbi.nlm.nih.gov/pubmed/19295157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5714-08.2009
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