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CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies resistant to current chemotherapies or radiotherapies, which makes it urgent to identify new therapeutic targets for HCC. In this study, we found that checkpoint kinase 1 (CHK1) was frequently overexpressed and correlated with...

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Detalhes bibliográficos
Main Authors: Hong, Jian, Hu, Kaishun, Yuan, Yunfei, Sang, Yi, Bu, Qiangui, Chen, Guihua, Yang, Longjun, Li, Binkui, Huang, Pinzhu, Chen, Dongtai, Liang, Yi, Zhang, Ruhua, Pan, Jingxuan, Zeng, Yi-Xin, Kang, Tiebang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589177/
https://ncbi.nlm.nih.gov/pubmed/22585575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61380
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