Adenovirus Expressing Both Thymidine Kinase and Soluble PD1 Enhances Antitumor Immunity by Strengthening CD8 T-cell Response

Adenoviruses harboring the herpes simplex virus thymidine kinase (HSVtk) gene under the regulation of a trans-splicing ribozyme targeting human telomerase reverse transcriptase (hTERT-TR) show marked and specific antitumor activity. In addition to inducing tumor cell death by direct cytotoxicity, it...

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Detalhes bibliográficos
Main Authors: Shin, Seung-Pil, Seo, Hye-Hyun, Shin, Jae-Hun, Park, Hyung-Bae, Lim, Dong-Pyo, Eom, Hyeon-Seok, Bae, Yong-Soo, Kim, In-Hoo, Choi, Kyungho, Lee, Sang-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589170/
https://ncbi.nlm.nih.gov/pubmed/23337984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.252
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