The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.
Expression of a p53-associated protein, Mdm-2 (murine double minute-2), can inhibit p53-mediated transactivation. In this study, overexpression of the Mdm-2 protein was found to result in the immortalization of primary rat embryo fibroblasts (REFs) and, in conjunction with an activated ras gene, in...
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| Publicado no: | Mol Cell Biol |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358909/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8417333/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.1.301-306.1993 |
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