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Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively.

Binding of platelet-derived growth factor (PDGF) to the PDGF receptor (PDGFR) beta subunit triggers receptor tyrosine phosphorylation and the stable association of a number of signal transduction molecules, including phospholipase C gamma (PLC gamma), the GTPase activating protein of ras (GAP), and...

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Udgivet i:Mol Cell Biol
Principais autores: Valius, M, Bazenet, C, Kazlauskas, A
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358893/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7678051/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.1.133-143.1993
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