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Epigenetic epistatic interactions constrain the evolution of gene expression

Reduced activity of two genes in combination often has a more detrimental effect than expected. Such epistatic interactions not only occur when genes are mutated but also due to variation in gene expression, including among isogenic individuals in a controlled environment. We hypothesized that these...

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Bibliografske podrobnosti
Main Authors: Park, Solip, Lehner, Ben
Format: Artigo
Jezik:Inglês
Izdano: European Molecular Biology Organization 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588906/
https://ncbi.nlm.nih.gov/pubmed/23423319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2013.2
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