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The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain.

Expression of the recombinant human U1-70K protein in COS cells resulted in its rapid transport to the nucleus, even when binding to U1 RNA was debilitated. Deletion analysis of the U1-70K protein revealed the existence of two segments of the protein which were independently capable of nuclear local...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Romac, J M, Graff, D H, Keene, J D
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1994
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358839/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7516470/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.7.4662
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