Single-agent therapy with sorafenib or 5-FU is equally effective in human colorectal cancer xenograft—no benefit of combination therapy

BACKGROUND: We initiated this preclinical study in order to analyze the impact of sorafenib single treatment versus combination treatment in human colorectal cancer. METHODS: The effect of increasing sorafenib doses on proliferation, apoptosis, migration, and activation of signal cascades was analyz...

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Autori principali: Wehler, Thomas C., Hamdi, Swaantje, Maderer, Annett, Graf, Claudine, Gockel, Ines, Schmidtmann, Irene, Hainz, Michael, Berger, Martin R., Theobald, Matthias, Galle, Peter R., Moehler, Markus, Schimanski, Carl C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer-Verlag 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587684/
https://ncbi.nlm.nih.gov/pubmed/22983756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00384-012-1551-2
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