DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells

Recent studies have highlighted an apparently paradoxical link between self-renewal and senescence triggered by DNA damage in certain cell types. In addition, the finding that TP53 can suppress senescence has caused a re-evaluation of its functional role in regulating these outcomes. To investigate...

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Main Authors: Jackson, Thomas R., Salmina, Kristine, Huna, Anda, Inashkina, Inna, Jankevics, Eriks, Riekstina, Una, Kalnina, Zane, Ivanov, Andrey, Townsend, Paul A., Cragg, Mark S., Erenpreisa, Jekaterina
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587444/
https://ncbi.nlm.nih.gov/pubmed/23287532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23285
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