Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3(+) regulatory T cells

Polymorphisms in MHC class II molecules, in particular around β-chain position-57 (β57), afford susceptibility/resistance to multiple autoimmune diseases, including type 1 diabetes, through obscure mechanisms. Here, we show that the antidiabetogenic MHC class II molecule I-A(b) affords diabetes resi...

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Autores principales: Tsai, Sue, Serra, Pau, Clemente-Casares, Xavier, Yamanouchi, Jun, Thiessen, Shari, Slattery, Robyn M., Elliott, John F., Santamaria, Pere
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587200/
https://ncbi.nlm.nih.gov/pubmed/23401506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211391110
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