Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site

Hydrolysis of acetylcholine by acetylcholinesterase (AChE) is extremely rapid, with a second-order hydrolysis rate constant k(E) (often denoted k(cat)/K(M)) that approaches 10(8) M(−1)s(−1). AChE contains a deep active site gorge with two sites of ligand binding, an acylation site (or A-site) contai...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Beri, Veena, Auletta, Jeffrey T., Maharvi, Ghulam M., Wood, Juanita F., Fauq, Abdul H., Rosenberry, Terrone L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586822/
https://ncbi.nlm.nih.gov/pubmed/23047027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2012.09.017
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares