Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

Delivery of drugs and macromolecules to the central nervous system (CNS) is hindered by the blood–brain barrier (BBB). Several approaches have been used to overcome this hindrance to facilitate the treatment of various CNS diseases. We now present results showing that chimeric adeno-associated virus...

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Bibliografiske detaljer
Main Authors: Alonso, Angelika, Reinz, Eileen, Leuchs, Barbara, Kleinschmidt, Jürgen, Fatar, Marc, Geers, Bart, Lentacker, Ine, Hennerici, Michael G., de Smedt, Stefaan C., Meairs, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Methods - Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586801/
https://ncbi.nlm.nih.gov/pubmed/23423361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.64
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