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Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum
The Plasmodium falciparum histone deacetylase Sir2a localizes at telomeric regions where it contributes to epigenetic silencing of clonally variant virulence genes. Apart from telomeres, PfSir2a also accumulates in the nucleolus, which harbours the developmentally regulated ribosomal RNA genes. Here...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3586713/ https://ncbi.nlm.nih.gov/pubmed/23443558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2539 |
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