Genomic Variation by Whole-Genome SNP Mapping Arrays Predicts Time-to-Event Outcome in Patients with Chronic Lymphocytic Leukemia: A Comparison of CLL and HapMap Genotypes

Genomic abnormalities, such as deletions in 11q22 or 17p13, are associated with poorer prognosis in patients with chronic lymphocytic leukemia (CLL). We hypothesized that unknown regions of copy number variation (CNV) affect clinical outcome and can be detected by array-based single-nucleotide polym...

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Hauptverfasser: Schweighofer, Carmen D., Coombes, Kevin R., Majewski, Tadeusz, Barron, Lynn L., Lerner, Susan, Sargent, Rachel L., O'Brien, Susan, Ferrajoli, Alessandra, Wierda, William G., Czerniak, Bogdan A., Medeiros, L. Jeffrey, Keating, Michael J., Abruzzo, Lynne V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2013
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586684/
https://ncbi.nlm.nih.gov/pubmed/23273604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2012.09.006
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