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Permeation of Insulin, Calcitonin and Exenatide across Caco-2 Monolayers: Measurement Using a Rapid, 3-Day System

OBJECTIVES: Caco-2 monolayers are one of the most widely used in vitro models for prediction of intestinal permeability of therapeutic molecules. However, the conventional Caco-2 monolayer model has several drawbacks including labor-intensive culture process, unphysiological growth conditions, lack...

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Detalhes bibliográficos
Main Authors: Gupta, Vivek, Doshi, Nishit, Mitragotri, Samir
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586668/
https://ncbi.nlm.nih.gov/pubmed/23483881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057136
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