Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase.

We have used in vitro mutagenesis to examine in detail the roles of two modular protein domains, SH2 and SH3, in the regulation of the Abl tyrosine kinase. As previously shown, the SH3 domain suppresses an intrinsic transforming activity of the normally nontransforming c-Abl product in vivo. We show...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Mayer, B J, Baltimore, D
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 1994
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8164650/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.5.2883-2894.1994
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