Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: a PCCTC trial

PURPOSE: AGS-1C4D4 is a human monoclonal antibody against prostate stem cell antigen (PSCA), a cell-surface protein expressed by most prostate cancers. AGS-1C4D4 is produced in Chinese hamster ovary (CHO) cells and has an identical sequence to AGS-PSCA, an anti-PSCA antibody produced in mouse hybrid...

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Detalhes bibliográficos
Main Authors: Antonarakis, Emmanuel S., Carducci, Michael A., Eisenberger, Mario A., Denmeade, Samuel R., Slovin, Susan F., Jelaca-Maxwell, Kathy, Vincent, Martha E., Scher, Howard I., Morris, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586214/
https://ncbi.nlm.nih.gov/pubmed/22020316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1759-9
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