Age-related cataracts: Homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection

To determine whether high levels of homocysteine (Hcy) induce endoplasmic reticulum (ER) stress with suppression of the nuclear factor-erythroid-2-related factor 2 (Nrf2)-dependent antioxidant protection in lens epithelial cells (LECs). ER stress was acutely induced by exposure of LECs to 100 μM Hcy...

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Main Authors: Elanchezhian, Rajan, Palsamy, Periyasamy, Madson, Christian J., Lynch, David W., Shinohara, Toshimichi
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586200/
https://ncbi.nlm.nih.gov/pubmed/22964297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2012.08.017
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