Cardiovascular Safety of Anagrelide in Healthy Subjects: Effects of Caffeine and Food Intake on Pharmacokinetics and Adverse Reactions

BACKGROUND: Essential thrombocythaemia (ET) is a rare clonal myeloproliferative disorder characterized by a sustained elevation in platelet count and megakaryocyte hyperplasia. Anagrelide is used in the treatment of ET, where it has been shown to reduce platelet count. Anagrelide is metabolized by c...

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Detalhes bibliográficos
Main Authors: Martínez-Sellés, Manuel, Datino, Tomás, Figueiras-Graillet, Lourdes, Gama, Joubert G., Jones, Christopher, Franklin, Richard, Fernández-Avilés, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing AG 2012
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586167/
https://ncbi.nlm.nih.gov/pubmed/23184666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40261-012-0032-2
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