High Heregulin Expression Is Associated with Activated HER3 and May Define an Actionable Biomarker in Patients with Squamous Cell Carcinomas of the Head and Neck

PURPOSE: Tumors with oncogenic dependencies on the HER family of receptor tyrosine kinases (RTKs) often respond well to targeted inhibition. Our previous work suggested that many cell lines derived from squamous cell carcinomas of the head and neck (SCCHNs) depend on autocrine signaling driven by HE...

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主要な著者: Shames, David S., Carbon, Juliet, Walter, Kim, Jubb, Adrian M., Kozlowski, Cleopatra, Januario, Tom, An, Do, Fu, Ling, Xiao, Yuanyuan, Raja, Rajiv, Jiang, Brittany, Malekafzali, Ashi, Stern, Howard, Settleman, Jeff, Wilson, Timothy R., Hampton, Garret M., Yauch, Robert L., Pirzkall, Andrea, Amler, Lukas C.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586092/
https://ncbi.nlm.nih.gov/pubmed/23468880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056765
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