11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol

The atherogenic 7-oxysterols, 7-ketocholesterol (7-KC) and 7β-hydroxycholesterol (7βOHC), can directly impair arterial function. Inter-conversion of 7-KC and 7βOHC has recently been shown as a novel role for the glucocorticoid-metabolizing enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). S...

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Autors principals: Mitić, Tijana, Andrew, Ruth, Walker, Brian R., Hadoke, Patrick W.F.
Format: Artigo
Idioma:Inglês
Publicat: Editions Scientifiques Elsevier 2013
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585959/
https://ncbi.nlm.nih.gov/pubmed/22940536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2012.08.007
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