A constitutively activated erythropoietin receptor stimulates proliferation and contributes to transformation of multipotent, committed nonerythroid and erythroid progenitor cells.

If the env gene of spleen focus-forming virus (SFFV) is replaced by a cDNA encoding a constitutively active form of the erythropoietin receptor, EPO-R(R129C), the resultant recombinant virus, SFFVcEPO-R, induces transient thrombocytosis and erythrocytosis in infected mice. Clonogenic progenitor cell...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Longmore, G D, Pharr, P N, Lodish, H F
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1994
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358593/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8139532/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.4.2266-2277.1994
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