Increased Artemis levels confer radioresistance to both high and low LET radiation exposures

BACKGROUND: Artemis has a defined role in V(D)J recombination and has been implicated in the repair of radiation induced double-strand breaks. However the exact function(s) of Artemis in DNA repair and its preferred substrate(s) in vivo remain undefined. Our previous work suggests that Artemis is im...

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Autori principali: Sridharan, Deepa M, Whalen, Mary K, Almendrala, Donna, Cucinotta, Francis A, Kawahara, Misako, Yannone, Steven M, Pluth, Janice M
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585927/
https://ncbi.nlm.nih.gov/pubmed/22713703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-7-96
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