Feedback Regulations of miR-21 and MAPKs via Pdcd4 and Spry1 Are Involved in Arsenite-Induced Cell Malignant Transformation

OBJECTIVE: To establish the functions of miR-21 and the roles of two feedback regulation loops, miR-21-Spry1-ERK/NF-κB and miR-21-Pdcd4-JNK/c-Jun, in arsenite-transformed human embryo lung fibroblast (HELF) cells. METHODS: For arsenite-transformed HELF cells, apoptosis, clonogenicity, and capacity f...

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Detalhes bibliográficos
Main Authors: Shen, Lu, Ling, Min, Li, Yuan, Xu, Yuan, Zhou, Yun, Ye, Jing, Pang, Ying, Zhao, Yue, Jiang, Rongrong, Zhang, Jianping, Liu, Qizhan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585869/
https://ncbi.nlm.nih.gov/pubmed/23469214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057652
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