Structural–Functional Studies of Burkholderia cenocepaciad-Glycero-β-d-manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties

[Image: see text] As an essential constituent of the outer membrane of Gram-negative bacteria, lipopolysaccharide contributes significantly to virulence and antibiotic resistance. The lipopolysaccharide biosynthetic pathway therefore serves as a promising therapeutic target for antivirulence drugs a...

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Hauptverfasser: Lee, Ting-Wai, Verhey, Theodore B., Antiperovitch, Pavel A., Atamanyuk, Dmytro, Desroy, Nicolas, Oliveira, Chrystelle, Denis, Alexis, Gerusz, Vincent, Drocourt, Elodie, Loutet, Slade A., Hamad, Mohamad A., Stanetty, Christian, Andres, Sara N., Sugiman-Marangos, Seiji, Kosma, Paul, Valvano, Miguel A., Moreau, Francois, Junop, Murray S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2012
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585733/
https://ncbi.nlm.nih.gov/pubmed/23256532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301483h
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