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Mechanism of polarized lysosome exocytosis in epithelial cells

Fusion of lysosomes with the plasma membrane is a calcium-dependent process that is crucial for membrane repair, limiting pathogen entry and clearing cellular debris. In non-polarized cells, lysosome exocytosis facilitates rapid resealing of torn membranes. Here, we investigate the mechanism of lyso...

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Detalhes bibliográficos
Main Authors: Xu, Jin, Toops, Kimberly A., Diaz, Fernando, Carvajal-Gonzalez, Jose Maria, Gravotta, Diego, Mazzoni, Francesca, Schreiner, Ryan, Rodriguez-Boulan, Enrique, Lakkaraju, Aparna
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585513/
https://ncbi.nlm.nih.gov/pubmed/23038769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.109421
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