TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, body...

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Main Authors: Tsai, Vicky Wang-Wei, Macia, Laurence, Johnen, Heiko, Kuffner, Tamara, Manadhar, Rakesh, Jørgensen, Sebastian Beck, Lee-Ng, Ka Ki Michelle, Zhang, Hong Ping, Wu, Liyun, Marquis, Christopher Peter, Jiang, Lele, Husaini, Yasmin, Lin, Shu, Herzog, Herbert, Brown, David A., Sainsbury, Amanda, Breit, Samuel N.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585300/
https://ncbi.nlm.nih.gov/pubmed/23468844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055174
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