The Selective Phosphodiesterase 4 Inhibitor Roflumilast and Phosphodiesterase 3/4 Inhibitor Pumafentrine Reduce Clinical Score and TNF Expression in Experimental Colitis in Mice

OBJECTIVE: The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of pro-inflammatory cytokine synthesis. We examined the effect of roflumilast, a selective PDE4 inhibitor marketed for severe COPD, and the inves...

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Bibliographic Details
Main Authors: Rieder, Florian, Siegmund, Britta, Bundschuh, Daniela S., Lehr, Hans-Anton, Endres, Stefan, Eigler, Andreas
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585290/
https://ncbi.nlm.nih.gov/pubmed/23468885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056867
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