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Mutations in Critical Domains Confer the Human mTOR Gene Strong Tumorigenicity
Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates cell growth, proliferation, and survival. mTOR is frequently activated in human cancers and is a commonly sought anticancer therapeutic target. However, whether the human mTOR gene itself is a proto-oncogene pos...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3585084/ https://ncbi.nlm.nih.gov/pubmed/23322780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399485 |
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